Decrease in serum level of matrix metalloproteinases is predictive of the disease-modifying effect of osteoarthritis drugs assessed by quantitative MRI in patients with knee osteoarthritis

J-P Pelletier; J-P Raynauld; J Caron; F Mineau; F Abram; M Dorais; B Haraoui; D Choquette; J Martel-Pelletier

doi:10.1136/ard.2009.122002

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Clinical and epidemiological research

Extended report

Decrease in serum level of matrix metalloproteinases is predictive of the disease-modifying effect of osteoarthritis drugs assessed by quantitative MRI in patients with knee osteoarthritis

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	Abstract	Full	Pdf
Jun 2010	59	3	21
Jul 2010	141	2	33
Aug 2010	108	2	17
Sep 2010	39	3	16
Oct 2010	41	2	17
Nov 2010	121	11	67
Dec 2010	83	22	57
Jan 2011	45	12	21
Feb 2011	40	6	12
Mar 2011	44	18	20
Apr 2011	27	24	24
May 2011	17	12	11
Jun 2011	28	26	21
Jul 2011	22	15	17
Aug 2011	28	8	8
Sep 2011	21	7	12
Oct 2011	29	14	14
Nov 2011	52	8	8
Dec 2011	41	5	8
Jan 2012	63	3	6
Feb 2012	39	4	1
Mar 2012	36	7	4
Apr 2012	45	6	8
May 2012	51	5	3
Jun 2012	45	9	7
Jul 2012	42	3	6
Aug 2012	32	3	6
Sep 2012	60	1	4
Oct 2012	45	10	8
Nov 2012	50	3	4
Dec 2012	20	1	4
Jan 2013	325	4	6
Feb 2013	40	10	9
Mar 2013	29	7	6
Apr 2013	40	10	8
May 2013	24	0	1
Jun 2013	32	5	9
Jul 2013	25	3	4
Aug 2013	29	8	7
Sep 2013	25	5	8
Oct 2013	28	8	8
Nov 2013	40	10	13
Dec 2013	14	5	6
Jan 2014	13	7	5
Feb 2014	35	3	7
Mar 2014	41	4	7
Apr 2014	40	4	5
May 2014	28	7	4
Jun 2014	29	5	9
Jul 2014	37	3	2
Aug 2014	14	7	6
Sep 2014	16	3	3
Oct 2014	33	5	5
Nov 2014	27	2	4
Dec 2014	18	4	6
Jan 2015	14	6	6
Feb 2015	24	4	6
Mar 2015	14	12	10
Apr 2015	15	4	8
May 2015	12	5	5
Jun 2015	24	7	5
Jul 2015	8	6	2
Aug 2015	21	9	6
Sep 2015	36	4	7
Oct 2015	13	6	6
Nov 2015	14	3	4
Dec 2015	22	0	0
Jan 2016	25	1	0
Feb 2016	22	6	8
Mar 2016	23	6	3
Apr 2016	43	6	9
May 2016	9	4	5
Jun 2016	16	5	6
Jul 2016	12	5	6
Aug 2016	12	3	2
Sep 2016	16	1	4
Oct 2016	10	1	9
Nov 2016	23	0	0
Dec 2016	87	1	1
Jan 2017	15	1	2
Feb 2017	18	3	7
Mar 2017	15	5	4
Apr 2017	21	2	1
May 2017	28	1	1
Jun 2017	39	8	8
Jul 2017	65	6	4
Aug 2017	62	1	1
Sep 2017	55	5	3
Oct 2017	51	6	4
Nov 2017	40	1	1
Dec 2017	51	2	1
Jan 2018	45	3	4
Feb 2018	78	5	5
Mar 2018	46	5	3
Apr 2018	49	4	2
May 2018	40	9	4
Jun 2018	60	10	5
Jul 2018	48	13	5
Aug 2018	74	3	2
Sep 2018	38	1	1
Oct 2018	62	6	4
Nov 2018	35	3	1
Dec 2018	37	3	3
Jan 2019	17	5	4
Feb 2019	46	3	1
Mar 2019	67	2	1
Apr 2019	26	0	3
May 2019	20	2	1
Jun 2019	21	2	1
Jul 2019	25	3	3
Aug 2019	25	9	0
Sep 2019	22	3	1
Oct 2019	51	5	2
Nov 2019	33	5	0
Dec 2019	50	4	2
Jan 2020	45	3	1
Feb 2020	19	4	3
Mar 2020	24	3	3
Apr 2020	39	2	3
May 2020	43	0	0
Jun 2020	22	2	2
Jul 2020	29	1	3
Aug 2020	36	2	1
Sep 2020	49	1	0
Oct 2020	37	9	3
Nov 2020	30	5	6
Dec 2020	44	4	0
Jan 2021	58	5	1
Feb 2021	72	4	2
Mar 2021	29	5	5
Apr 2021	33	1	1
May 2021	28	1	0
Jun 2021	1	1	2
Jul 2021	1	1	1
Aug 2021	1	1	0
Sep 2021	3	3	1
Oct 2021	7	0	1
Nov 2021	48	4	2
Dec 2021	63	4	2
Jan 2022	54	2	0
Feb 2022	94	3	0
Mar 2022	46	6	1
Apr 2022	41	8	0
May 2022	71	6	3
Jun 2022	66	3	0
Jul 2022	44	5	2
Aug 2022	50	4	1
Sep 2022	70	6	2
Oct 2022	113	8	4
Nov 2022	54	4	4
Dec 2022	53	1	0
Jan 2023	129	8	2
Feb 2023	68	4	2
Mar 2023	70	6	0
Apr 2023	33	5	1
May 2023	43	4	2
Jun 2023	25	3	0
Jul 2023	56	6	3
Aug 2023	25	1	0
Sep 2023	46	2	0
Oct 2023	28	4	0
Nov 2023	56	3	0
Dec 2023	51	8	1
Jan 2024	69	4	2
Feb 2024	20	1	0
Mar 2024	54	1	0
Total	6776	820	899

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