Insulin-like growth factor 1 blocks collagen release and down regulates matrix metalloproteinase-1, -3, -8, and -13 mRNA expression in bovine nasal cartilage stimulated with oncostatin M in combination with interleukin 1α

W Hui; A D Rowan; T Cawston

doi:10.1136/ard.60.3.254

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Extended report

Insulin-like growth factor 1 blocks collagen release and down regulates matrix metalloproteinase-1, -3, -8, and -13 mRNA expression in bovine nasal cartilage stimulated with oncostatin M in combination with interleukin 1α

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Online download statistics by month: February 2001 to March 2024

	Abstract	Full	Pdf
Feb 2001	19	31	17
Mar 2001	10	42	54
Apr 2001	2	35	13
May 2001	9	34	7
Jun 2001	4	21	1
Jul 2001	2	38	13
Aug 2001	1	24	9
Sep 2001	3	11	1
Oct 2001	1	23	7
Nov 2001	0	10	6
Dec 2001	3	12	2
Jan 2002	0	16	5
Feb 2002	1	8	1
Mar 2002	1	12	5
Apr 2002	3	10	2
May 2002	1	7	3
Jun 2002	1	7	3
Jul 2002	3	7	5
Aug 2002	1	5	5
Sep 2002	1	7	1
Oct 2002	0	12	17
Nov 2002	1	13	5
Dec 2002	2	4	9
Jan 2003	1	9	3
Feb 2003	0	5	0
Mar 2003	4	8	3
Apr 2003	1	11	6
May 2003	3	3	3
Jun 2003	0	8	4
Jul 2003	9	37	7
Aug 2003	11	16	3
Sep 2003	12	13	4
Oct 2003	9	29	5
Nov 2003	18	24	4
Dec 2003	16	18	4
Jan 2004	23	47	5
Feb 2004	18	14	3
Mar 2004	24	19	0
Apr 2004	14	19	6
May 2004	44	52	11
Jun 2004	47	57	15
Jul 2004	42	61	8
Aug 2004	37	53	4
Sep 2004	19	42	9
Oct 2004	12	54	10
Nov 2004	7	33	4
Dec 2004	8	28	14
Jan 2005	14	32	11
Feb 2005	12	28	4
Mar 2005	13	31	17
Apr 2005	8	22	12
May 2005	12	39	22
Jun 2005	3	17	6
Jul 2005	8	7	5
Aug 2005	6	6	8
Sep 2005	6	8	7
Oct 2005	5	22	17
Nov 2005	6	12	7
Dec 2005	4	13	4
Jan 2006	4	23	10
Feb 2006	4	17	5
Mar 2006	2	15	7
Apr 2006	3	16	9
May 2006	3	18	10
Jun 2006	3	9	6
Jul 2006	2	15	10
Aug 2006	4	13	8
Sep 2006	9	6	9
Oct 2006	8	16	6
Nov 2006	6	18	10
Dec 2006	3	16	9
Jan 2007	0	19	3
Feb 2007	6	15	2
Mar 2007	7	11	6
Apr 2007	7	4	2
May 2007	6	4	4
Jun 2007	9	13	4
Jul 2007	7	12	2
Aug 2007	8	5	4
Sep 2007	6	6	3
Oct 2007	10	2	4
Nov 2007	8	6	2
Dec 2007	3	2	0
Jan 2008	7	3	4
Feb 2008	14	6	3
Mar 2008	37	7	4
Apr 2008	6	1	0
May 2008	38	8	3
Jun 2008	7	3	1
Jul 2008	38	1	1
Aug 2008	73	1	0
Sep 2008	46	2	0
Oct 2008	63	1	2
Nov 2008	34	0	0
Dec 2008	6	2	1
Jan 2009	12	0	4
Feb 2009	8	3	2
Mar 2009	50	0	1
Apr 2009	22	0	0
May 2009	6	2	2
Jun 2009	11	1	0
Jul 2009	9	1	0
Aug 2009	7	0	0
Sep 2009	17	2	2
Oct 2009	51	3	1
Nov 2009	25	1	1
Dec 2009	15	0	8
Jan 2010	1	3	1
Feb 2010	4	0	1
Mar 2010	3	3	3
Apr 2010	5	1	1
May 2010	2	5	3
Jun 2010	11	1	2
Jul 2010	23	0	3
Aug 2010	4	8	1
Sep 2010	2	1	0
Oct 2010	5	3	1
Nov 2010	5	0	0
Dec 2010	4	3	0
Jan 2011	7	3	2
Feb 2011	8	2	0
Mar 2011	13	4	3
Apr 2011	7	3	0
May 2011	5	3	2
Jun 2011	14	2	0
Jul 2011	3	1	0
Aug 2011	8	2	2
Sep 2011	7	1	0
Oct 2011	4	0	0
Nov 2011	10	5	1
Dec 2011	9	12	6
Jan 2012	4	7	8
Feb 2012	5	8	6
Mar 2012	7	4	2
Apr 2012	9	5	3
May 2012	7	5	6
Jun 2012	10	5	2
Jul 2012	7	13	11
Aug 2012	9	15	13
Sep 2012	10	13	7
Oct 2012	7	10	8
Nov 2012	8	17	8
Dec 2012	7	11	3
Jan 2013	8	12	6
Feb 2013	10	15	12
Mar 2013	8	11	3
Apr 2013	6	11	3
May 2013	8	7	4
Jun 2013	7	8	2
Jul 2013	4	7	2
Aug 2013	4	5	3
Sep 2013	8	11	3
Oct 2013	3	7	0
Nov 2013	1	3	3
Dec 2013	5	12	4
Jan 2014	7	8	4
Feb 2014	5	11	3
Mar 2014	11	11	2
Apr 2014	9	13	2
May 2014	27	12	2
Jun 2014	11	25	9
Jul 2014	11	20	3
Aug 2014	6	10	7
Sep 2014	11	6	5
Oct 2014	2	11	2
Nov 2014	5	17	3
Dec 2014	7	6	0
Jan 2015	5	8	0
Feb 2015	3	4	5
Mar 2015	1	8	4
Apr 2015	5	7	2
May 2015	9	7	2
Jun 2015	1	15	5
Jul 2015	3	12	5
Aug 2015	4	9	0
Sep 2015	14	7	2
Oct 2015	3	9	1
Nov 2015	2	3	1
Dec 2015	5	12	2
Jan 2016	9	2	6
Feb 2016	6	4	0
Mar 2016	3	10	5
Apr 2016	8	7	2
May 2016	1	6	6
Jun 2016	2	8	11
Jul 2016	7	9	19
Aug 2016	7	5	12
Sep 2016	11	10	15
Oct 2016	9	14	8
Nov 2016	18	2	7
Dec 2016	7	7	9
Jan 2017	10	10	4
Feb 2017	1	6	3
Mar 2017	2	6	2
Apr 2017	1	7	6
May 2017	4	16	5
Jun 2017	2	7	2
Jul 2017	6	5	0
Aug 2017	12	10	2
Sep 2017	16	16	1
Oct 2017	21	11	0
Nov 2017	15	9	0
Dec 2017	342	340	6
Jan 2018	180	180	5
Feb 2018	116	110	3
Mar 2018	102	96	1
Apr 2018	125	121	1
May 2018	73	73	0
Jun 2018	56	50	2
Jul 2018	31	25	0
Aug 2018	138	132	4
Sep 2018	64	64	0
Oct 2018	80	76	3
Nov 2018	81	79	4
Dec 2018	68	66	2
Jan 2019	71	70	1
Feb 2019	53	53	2
Mar 2019	31	29	3
Apr 2019	18	18	4
May 2019	8	9	2
Jun 2019	17	15	6
Jul 2019	13	13	6
Aug 2019	14	12	7
Sep 2019	15	15	13
Oct 2019	10	10	5
Nov 2019	13	13	4
Dec 2019	9	9	7
Jan 2020	10	10	2
Feb 2020	7	7	4
Mar 2020	6	6	4
Apr 2020	12	12	0
May 2020	15	10	5
Jun 2020	17	17	6
Jul 2020	10	10	3
Aug 2020	8	8	5
Sep 2020	20	19	2
Oct 2020	13	10	8
Nov 2020	13	7	3
Dec 2020	16	14	1
Jan 2021	12	12	3
Feb 2021	5	5	4
Mar 2021	15	9	8
Apr 2021	10	10	4
May 2021	12	11	2
Jun 2021	9	9	3
Jul 2021	14	14	1
Aug 2021	10	10	4
Sep 2021	10	10	6
Oct 2021	13	11	18
Nov 2021	13	13	17
Dec 2021	7	7	2
Jan 2022	26	27	11
Feb 2022	10	9	3
Mar 2022	13	17	6
Apr 2022	9	11	3
May 2022	30	24	9
Jun 2022	22	22	9
Jul 2022	14	14	4
Aug 2022	39	39	3
Sep 2022	26	24	12
Oct 2022	27	27	3
Nov 2022	26	26	3
Dec 2022	25	25	2
Jan 2023	28	20	5
Feb 2023	52	49	3
Mar 2023	19	17	4
Apr 2023	19	18	2
May 2023	6	4	9
Jun 2023	18	14	5
Jul 2023	11	12	6
Aug 2023	10	8	8
Sep 2023	9	9	10
Oct 2023	18	18	0
Nov 2023	36	32	3
Dec 2023	44	8	0
Jan 2024	73	0	0
Feb 2024	69	0	0
Mar 2024	100	0	0
Total	4730	4744	1300

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