Five SNPs showing significant association at the genome-wide significance level and one suggestive SNP
| Allele* | GWAS stage‡ | REP1 stage§ | REP2 stage¶ | Meta-analysis** | ||||||||||||||||||
| Risk allele frequency | Risk allele frequency | Risk allele frequency | Fixed-effect model | Random-effect model | Cochran's Q | |||||||||||||||||
| SNP | A/B | Chr | Position† | Gene | Case | Control | OR (95% CI) | P value | Case | Control | OR (95% CI) | P value | Case | Control | OR (95% CI) | P value | OR (95% CI) | P value | OR (95% CI) | P value | P value | I 2 |
| rs2728125 | G/A | 4 | 89 001 893 | ABCG2 | 0.401 | 0.304 | 1.54 (1.35 to 1.76) | 1.76×10−10 | 0.400 | 0.313 | 1.46 (1.31 to 1.64) | 5.33×10−11 | NA | NA | NA | NA | 1.49 (1.37 to 1.63) | 6.58×10−20 | 1.49 (1.37 to 1.63) | 6.58×10−20 | 0.57 | 0 |
| rs671 | C/T | 12 | 112 241 766 | ALDH2 | 0.821 | 0.751 | 1.52 (1.30 to 1.77) | 1.33×10−7 | 0.821 | 0.760 | 1.44 (1.26 to 1.65) | 5.94×10−8 | NA | NA | NA | NA | 1.47 (1.33 to 1.63) | 4.44×10−14 | 1.47 (1.33 to 1.63) | 4.44×10−14 | 0.62 | 0 |
| rs1014290 | T/C | 4 | 10 001 861 | SLC2A9 | 0.678 | 0.623 | 1.28 (1.12 to 1.46) | 2.75×10−4 | 0.674 | 0.611 | 1.31 (1.17 to 1.47) | 2.03×10−6 | NA | NA | NA | NA | 1.30 (1.19 to1.41) | 2.29×10−9 | 1.30 (1.19 to 1.41) | 2.29×10−9 | 0.76 | 0 |
| rs7927466 | A/G | 11 | 100 141 763 | CNTN5 | 0.976 | 0.953 | 1.99 (1.39 to 2.85) | 1.59×10−4 | 0.973 | 0.954 | 1.74 (1.30 to 2.33) | 2.29×10−4 | 0.976 | 0.954 | 1.91 (1.16 to 3.12) | 1.03×10−2 | 1.85 (1.50 to 2.27) | 5.33×10−9 | 1.85 (1.50 to 2.27) | 5.33×10−9 | 0.84 | 0 |
| rs9952962 | C/T | 18 | 27 535 568 | MIR302F | 0.549 | 0.486 | 1.29 (1.14 to 1.46) | 8.07×10−5 | 0.547 | 0.506 | 1.18 (1.06 to 1.31) | 2.97×10−3 | 0.552 | 0.490 | 1.28 (1.09 to 1.51) | 2.92×10−3 | 1.24 (1.15 to 1.33) | 1.67×10−8 | 1.24 (1.15 to 1.33) | 1.67×10−8 | 0.50 | 0 |
| rs12980365 | A/G | 19 | 23 395 317 | ZNF724 | 0.976 | 0.957 | 1.84 (1.27 to 2.65) | 1.12×10−3 | 0.974 | 0.959 | 1.61 (1.19 to 2.18) | 1.97×10−3 | 0.975 | 0.948 | 2.09 (1.29 to 3.36) | 2.58×10−3 | 1.77 (1.43 to 2.18) | 9.76×10−8 | 1.77 (1.43 to 2.18) | 9.76×10−8 | 0.65 | 0 |
*Allele A is risk-associated allele, and allele B is non-risk-associated allele.
†SNP positions are based on NCBI human genome reference sequence Build 37.4.
‡945 gout cases and 1003 AHUA controls.
§1499 gout cases and 1186 AHUA controls.
¶416 gout cases and 960 AHUA controls.
**Meta-analyses of the combined GWAS and replication samples (2860 gout cases and 3149 controls of Japanese men).
AHUA, asymptomatic hyperuricaemia; Chr, Chromosome; GWAS, genome-wide association study;NCBI, National Center for Biotechnology Information; REP1, the first replication; REP2, the second replication;SNP, single nucleotide polymorphism.