Risk of developing rheumatoid arthritis (RA) in women with different combinations of occupational textile dust exposure and shared epitope (SE) genes compared with women who reported no exposure to textile dust and carrying no SE genes, Malaysian Epidemiological Investigation of Rheumatoid Arthritis study*
| No SE | Any SE | |||
|---|---|---|---|---|
| Ca/Co | OR (95% CI) | Ca/Co | OR (95% CI) | |
| Occupational exposure to textile dust | ||||
| RA overall | ||||
| Unexposed | 376/545 | Referent | 244/102 | 3.4 (2.7 to 4.3) |
| Ever exposed | 24/14 | 2.5 (1.3 to 4.9) | 17/1 | 25.1 (3.3 to 189.5) |
| AP: 0.8 (0.4 to 1.2)** | ||||
| ACPA-positive RA | ||||
| Unexposed | 201/545 | Referent | 198/102 | 5.1 (4.0 to 6.6) |
| Ever exposed | 9/14 | 1.8 (0.8 to 4.2) | 14/1 | 39.1 (5.1 to 297.5) |
| AP: 0.8 (0.5 to 1.2)** | ||||
| ACPA-negative RA | 175/545 | Referent | 46/102 | 1.5 (1.1 to 2.0) |
| Unexposed | 15/14 | 3.3 (1.6 to 6.9) | 3/1 | 9.3 (1.0 to 89.4) |
| Ever exposed | AP: 0.6 (−0.4 to 1.6) | |||
*All estimates adjusted for age group, geographical area, educational levels and ethnicity.
**p<0.0001.
ACPA, anti-citrullinated protein antibody; AP, attributable proportion due to interaction; Ca/Co, case/control.