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Hypothesis
Is progressive osteoarthritis an atheromatous vascular disease?
  1. P G Conaghan1,
  2. H Vanharanta2,
  3. P A Dieppe3
  1. 1Academic Unit of Musculoskeletal Disease, University of Leeds, Leeds UK
  2. 2Leeds Musculoskeletal Service, Leeds UK
  3. 3MRC Health Services Research Collaboration, University of Bristol, Bristol UK
  1. Correspondence to:
    Professor P G Conaghan
    Academic Unit of Musculoskeletal Disease, 2nd Floor Chapel Allerton Hospital, Chapeltown Road, Leeds LS7 4SA, UK; p.conaghanleeds.ac.uk

Abstract

Growing evidence from epidemiological studies suggests that osteoarthritis (OA) is linked to atheromatous vascular disease. This hypothesis article proposes that OA, or at least OA structural progression, may be an atheromatous vascular disease of subchondral bone. Further epidemiological studies, imaging investigations of relevant blood vessels, and trials of the effects of statins on the prevention and treatment of OA are needed to examine this hypothesis.

  • MRI, magnetic resonance imaging
  • NSAIDs, non-steroidal anti-inflammatory drugs
  • OA, osteoarthritis
  • osteoarthritis
  • atheromatous vascular disease
  • subchondral bone

https://doi.org/10.1136/ard.2005.039263

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