Combination therapy with sulfasalazine and methotrexate is more effective than either drug alone in patients with rheumatoid arthritis with a suboptimal response to sulfasalazine: results from the double-blind placebo-controlled MASCOT study
H. A Capell, R. Madhok, D. R Porter, R. A L Munro, I. B McInnes, J. A Hunter, M. Steven, A. Zoma, E. Morrison, M. Sambrook, F. Wui Poon, R. Hampson, F. McDonald, A. Tierney, N. Henderson, and I. Ford
The 2nd to last paragraph on page 239 should have read as follows and not as published the error is regretted:
The "step-up" approach was used rather than "sustained
continuous" or "step-down" regimens, because this approach is often adopted in clinical practice. In a double-blind controlled randomised study, O'Dell et al compared parallel sustained treatment with MTX, SASP and HCQ against MTX alone, and SASP and HCQ in patients with established rheumatoid arthritis.10 11 Low-dose oral prednisolone was permitted in their studies. Although the patients had more severe disease than in the MASCOT study, the results are comparable, as both showed
improvement in measures of clinical synovitis, but no difference in ESR as a single measure. O'Dell et al did not report on radiological outcome.
