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Figure 6

Figure 6
Figure 6

Effects of the specific matrix metalloproteinase 13 (MMP-13) inhibitor (30 mg/kg/day) in the antigen-induced arthritis (AIA) model in rabbits (normal rabbits n=2, arthritic animals (=vehicle) n=6, MMP-13 inhibitor treated n=7). The induction of AIA in untreated animals served as a positive control. (A) Treatment with the MMP-13 inhibitor did not significantly decrease the loss off proteoglycan. (B) The histological analysis of the cartilage erosions showed a non-significant downregulation of erosions by 14% in animals treated with the MMP-13 inhibitor.

Vol 83 Issue 5 Table of Contents
Annals of the Rheumatic Diseases: 83 (5)
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