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1 Department of Internal Medicine C, Sheba Medical Centre,Tel-Hashomer, Israel
2 Thrombosis and Haemostasis Research Institute, Sheba Medical Centre
3 Institute of Lipid and Atherosclerosis Research, Sheba Medical Centre
4 Institute of Chemical Pathology, Sheba Medical Centre
5 Department of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, California, USA
6 Department of Internal Medicine F, Sheba Medical Centre
7 Statistics Laboratory, Tel-Aviv University, Ramat-Aviv, Israel
Correspondence to:
Correspondence to:
Dr M Ehrenfeld
Department of Medicine C, Sheba Medical Centre, Tel-Hashomer 52621, Israel; ehrenfel{at}post.tau.ac.il
Background: Venous and arterial thromboses occur in patients with Behçet’s disease and are associated with significant morbidity and mortality. Studies on a possible association between the occurrence of thrombosis and thrombophilia in patients with this disease have been controversial.
Objective: To determine the prevalence of the most common thrombophilias and dyslipidaemia in patients with Behçet’s disease with and without thrombosis.
Methods: Blood samples from 107 patients with Behçet’s disease who had or did not have thrombosis were analysed for factor V Leiden, prothrombin G20210A polymorphism, methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism, factor VIII level, homocysteine and C reactive protein concentrations, dyslipidaemia, and plasma glucosylceramide.
Results: There was no difference between patients with and without thrombosis in the prevalence of prothrombin G20210A polymorphism, factor V Leiden, homozygous MTHFR C677T, or plasma concentrations of homocysteine, C reactive protein, or glucosylceramide. In contrast, patients with thrombosis were found to have significantly higher mean levels of factor VIII, total cholesterol, triglycerides, VLDL cholesterol, and apolipoproteins B-100, C-II, and C-III than those without thrombosis. Multistepwise logistic regression analysis showed that triglyceride concentration was the best marker associated with thrombosis (p = 0.008), with an estimated odds ratio of 1.58 (95% confidence interval, 1.09 to 2.30) for a difference of 40 mg/dl.
Conclusions: Thrombophilia does not seem to play a major role in the tendency to thrombosis in Behçet’s disease. However, dyslipidaemia, predominantly hypertriglyceridaemia, might be a risk factor.
Abbreviations: DVT, deep vein thrombosis; Lp(a), lipoprotein (a); MTHFR, methylenetetrahydrofolate reductase; SVT, superficial vein thrombosis
Keywords: Behçet’s disease; thrombophilia; dyslipidaemia; factor VIII
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