HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER		Author Keyword(s) Vol Page [Advanced]

This Article Full Text Full Text (PDF) Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this link to a friend Similar articles in this journal Similar articles in PubMed Add article to my folders Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Pluijm, S M F Articles by Lips, P Search for Related Content PubMed PubMed Citation Articles by Pluijm, S M F Articles by Lips, P

Collagen type I 1 Sp1 polymorphism, osteoporosis, and intervertebral disc degeneration in older men and women

¹ Institute for Research in Extramural Medicine (EMGO Institute), VU University Medical Centre (Vumc), Amsterdam, The Netherlands
² Department of Endocrinology, VU University Medical Centre (Vumc), Amsterdam, The Netherlands
³ Department of Internal Medicine, Erasmus University Medical School, Rotterdam, The Netherlands
⁴ Department of Sociology and Social Gerontology, Vrije Universiteit, Amsterdam, The Netherlands

Correspondence to:
Correspondence to:
Dr P Lips
Department of Endocrinology, VU University Medical Centre (Vumc), PO Box 7057, 1007 MB Amsterdam, The Netherlands; p.lips{at}vumc.nl

Objectives: To examine whether collagen type I 1 (COLIA1) Sp1 polymorphism is associated with osteoporosis and/or intervertebral disc degeneration in older people.

Methods: COLIA1 genotype was determined in 966 men and women (65 years) of the Longitudinal Aging Study Amsterdam. The guanine (G) to thymidine (T) polymorphism in the first intron of the COLIA1 gene was detected by PCR and MscI digestion. In the total sample, quantitative ultrasound (QUS) measurements, serum osteocalcin (OC), and urine deoxypyridinoline (DPD/Cr_urine) were assessed. A follow up of fractures was done every three months. In a subsample, total body bone mineral content (n = 485) and bone mineral density (BMD) of the hip and lumbar spine (n = 512) were measured by dual energy x ray absorptiometry (DXA). Prevalent vertebral deformities and intervertebral disc degeneration were identified on radiographs (n = 517).

Results: People with the TT genotype had a higher risk of disc degeneration than those with the GG and GT genotypes (OR = 3.6; 95% CI 1.3 to 10). For men, higher levels of OC were found in those with the T allele than in those without it (GG v (GT+TT) 1.96 (0.06) nmol/l v 2.19 (0.09) nmol/l). COLIA1 polymorphism was not significantly associated with other measures of osteoporosis in either men or women.

Conclusion: COLIA1 Sp1 polymorphism may be a genetic risk factor related to intervertebral disc degeneration in older people. Previously reported associations between the COLIAI Sp1 genotype and lower BMD or QUS values, higher levels of DPD/Cr, and an increased fracture risk in either men or women could not be confirmed.

Keywords: COLIA1 Sp1 polymorphism; osteoporosis; fractures; disk degeneration; genetic risk factor

Abbreviations: ANOVA, analysis of variance; BMC, bone mineral content; BMD, bone mineral density; BUA, broadband ultrasound attenuation; CI, confidence interval; COLIA1, collagen type I 1; DPD, deoxypyridinoline; DXA, dual energy x ray absorptiometry; G, guanine; JSN, joint space narrowing; LASA, Longitudinal Aging Study Amsterdam; OA, osteoarthritis; OR, odds ratio; PCR, polymerase chain reaction; QUS, quantitative ultrasound; RR, relative risk; SOS, speed of sound; T, thymidine; VUMC, VU University Medical Centre

This article has been cited by other articles:

				A. J. Freemont The cellular pathobiology of the degenerate intervertebral disc and discogenic back pain Rheumatology, October 14, 2008; (2008) ken396v1. [Abstract] [Full Text] [PDF]

				J J Ryder, K Garrison, F Song, L Hooper, J Skinner, Y Loke, J Loughlin, J P T Higgins, and A J MacGregor Genetic associations in peripheral joint osteoarthritis and spinal degenerative disease: a systematic review Ann Rheum Dis, May 1, 2008; 67(5): 584 - 591. [Abstract] [Full Text] [PDF]

				M. E. Kevenaar, A. P.N. Themmen, F. Rivadeneira, A. G. Uitterlinden, J. S.E. Laven, N. M. van Schoor, P. Lips, H. A.P. Pols, and J. A. Visser A polymorphism in the AMH type II receptor gene is associated with age at menopause in interaction with parity Hum. Reprod., September 1, 2007; 22(9): 2382 - 2388. [Abstract] [Full Text] [PDF]

				A. G. Uitterlinden, S. H. Ralston, M. L. Brandi, A. H. Carey, D. Grinberg, B. L. Langdahl, P. Lips, R. Lorenc, B. Obermayer-Pietsch, J. Reeve, et al. The Association between Common Vitamin D Receptor Gene Variations and Osteoporosis: A Participant-Level Meta-Analysis Ann Intern Med, August 15, 2006; 145(4): 255 - 264. [Abstract] [Full Text] [PDF]

				C Tilkeridis, T Bei, S Garantziotis, and C A Stratakis Association of a COL1A1 polymorphism with lumbar disc disease in young military recruits J. Med. Genet., July 1, 2005; 42(7): e44 - e44. [Abstract] [Full Text] [PDF]